Case Report The authors present the case of a 68 year-old man with chronic alcoholic pancreatitis, who presented to the emergency department for abdominal pain and jaundice. Laboratory tests revealed markedly hyperbilirubinemia and cholestasis. Abdominal ultrasound showed dilatation of the common bile with apparent distal stenosis. Abdominal CT revealed the presence of an 40 mm hypodense cephalopancreatic lesion, with cystic areas, and involvement of the hepatic artery. Adjacent suspicious enlarged lymph nodes were observed. A transendoscopic ultrasonography was then performed confirming the presence of a multiloculated cystic lesion with a solid component (Fig. 1), conditioning dilatation of the common bile duct and Wirsung’s duct (Fig. 2). An EUS-guided fine needle aspiration was done for further characterization (Fig. 3). Fig 1. – Pancreatic multiloculated cystic lesion with a solid component, located in the head of the pancreas. Fig 2. – Dilatation of the common bile duct and Wirsung’s duct. Fig 3. – EUS-guided fine needle aspiration for further characterization.   For relief of jaundice it was decided to perform ERCP. With the side-view endoscope a patulous ampulla of Vater with extruding mucus was observed, the so-called fish-mouth sign (Fig. 4), pathognomonic for a main branch intraductal pancreatic mucinous neoplasm (IPMN). Given the invasion of local structures, malignant transformation of the IPMN was assumed, and a short self-expanding metal stent was placed for drainage of the common bile duct (Fig. 5) and allowing neoadjuvant therapy. Fig 4. – Patulous ampulla of Vater with extruding mucus, the so-called fish-mouth sign, pathognomonic for a main branch IPMN. […]

Case report A 59-year-old male with unremarkable past clinical history, presented to the Emergency Department with acute abdominal pain in the left lower quadrant, with a constant, non-irradiating pattern of two days duration. He denied any changes in bowel movements, blood loss, bloating, weight loss or fever. There were no alleviating or aggravating factors. He was afebrile, hemodynamically stable, with abdominal tenderness on palpation of the left lower quadrant but no palpable masses, guarding or rebound. His laboratory tests showed normal hemoglobin, mild elevation of inflammatory markers (leukocyte count 12.000^10/L, CRP 5 mg/dL) and normal liver and renal tests. A point-of-care ultrasound without bowel preparation was performed in the emergency room that showed an area of sigmoid wall thickening, with echo-poor protrusion from the colonic wall, with surrounding hyperechoic fat stranding, suggestive of acute diverticular disease (Fig. 1). Fig. 1 – Hypoechoic protrusion from the thickened colonic wall with surrounding fat stranding – diverticulitis. In the same area, we identified a 20mm, hyperechoic, round-shaped, well-circumscribed, polypoid protrusion of the sigmoid wall into the colonic lumen, with no signs of obstruction or intussusception, and absent blood flow on color Doppler sonography (Fig. 2). These findings were indicative of a colonic lipoma. Fig. 2 – Hyperechoic, well-circumscribed, non-vascular protrusion into the sigmoid lumen – colonic lipoma. The patient was started on iv antibiotics, with quick clinical and laboratory improvement. He eventually underwent a colonoscopy that confirmed the diagnosis of colonic lipoma and diverticular disease (Fig. 3). On follow-up, the patient had no […]

Case Report An 81 year old woman presented to the emergency room with one week history of abdominal pain and general weakness. The abdominal CT scan showed a 30mm mass in the body of the pancreas, suggestive of a neoplastic process, so the patient was scheduled for an EUS for local staging and tissue sampling . The endoscopic ultrasound confirmed a 26 mm mass in the neck of the pancreas, c uT2N0 (Fig. 1). Fig. 1 – Pancreatic tumor. On withdrawal, during the posterior mediastinum scanning, we identified a hypo-echoic mass that occupied almost 90% of the left pulmonary artery (Fig. 2). An angioCT scan later confirmed the pulmonary embolism and the patient was started on anticoagulation therapy. Fig. 2 – Thrombus in left pulmonary artery (LPA)   Commentary As the number of EUS procedures increases, gastroenterologists will be expected to identify more incidental findings in structures beyond the GI tract that could have an impact on patient´s management and prognosis. Therefore, a methodic evaluation of all the surrounding systems, beyond the scope of the exam, is crucial.   Authors Irina Mocanu1, Rita Barosa2, Marta Patita2, Gonçalo Nunes2, Pedro Pinto Marques2 1. Gastroenterology Department, Hospital Espírito Santo, Évora 2. Gastroenterology Department, Hospital Garcia de Orta, Almada.

Case Report We present the case of a 69-year-old woman with past history of bilateral breast carcinoma, treated with surgery and radiotherapy in 2006 and 2012, in clinical remission for the past 4 years. She had no other recent symptoms or clinical diagnosis. Following hereditary neoplastic syndromes surveillance protocol, the patient was submitted to an upper GI endoscopy, where a small submucosal lesion of the gastric antrum was identified and the patient was subsequently scheduled for an upper GI endosonography (EUS). Cardiac examination, laboratory tests and electrocardiogram were performed and were normal. At EUS, a small lipoma in the submucosal layer of the antrum was diagnosed. At mediastinal observation, a 12mm, isoechoic mass bulging from the inter-auricular septum into the left atrium was identified. The mass had no relation with the valvar ring (Figure 1). Figure 1. Mediastinal EUS showing a bulging mass in the left atrium (LA). The patient was immediately admitted for further investigations. The transesophageal echocardiography confirmed the presence of a small mass of the auricular septum and excluded thrombi or cardiac failure. There were no changes on chest and abdominal CT scan. At this point, the most plausible diagnosis was a cardiac myxoma, although the presence of a cardiac breast cancer metastasis could not be excluded, given the patient´s history. The following week, she underwent complete surgical resection of the tumor (Figure 2), with a confirming histology of cardiac myxoma. The post-operatory recovery was uneventful. Figure 2. Ex-vivo atrial mixoma.   Commentary Primary tumors of the heart are extremely rare, with […]

Case Report A 51-year-old Caucasian female with a previous history of depressive disorder and non‐steroidal anti-inflammatory drugs (NSAID) use for chronic pain by orthopaedic trauma was referred to our center due to epigastric pain, nausea and occasional vomiting during last 3 months. Physical examination, laboratory parameters and plain abdominal X-ray were unremarkable. Upper gastrointestinal endoscopy with biopsies revealed chronic pangastritis without dysplasia and positivity to Helicobacter pylori (Hp). No clinical improvement was verified following successful Hp eradication therapy and NSAID withdrawal. Abdominal ultrasound pointed to a possible wall thickening at the descending colon (0.70 cm x 4.3 cm) (Figure 1). Figure 1 – Abdominal ultrasound showing a thickening of the bowel wall with loss of layering.   Then, a total colonoscopy was performed with no abnormalities. Abdominal ultrasound was repeated and continued to show the same findings, but a small bowel origin was admitted. Therefore, an abdominopelvic CT and CT enterography were done, but both were normal (Figure 2). Figure 2 – Abdominopelvic CT (A) and CT enterography (B) with no abnormalities.   A few months after the onset of symptoms, the patient had clinical worsening with weigh loss (>10%) requiring hospital admission to parenteral nutrition. Despite a normal analytical study, abdominal ultrasound continued to show a small bowel thickening (0.88 cm in thickness), loss of wall lawering and additionally, several local lymphadenopathies and mild interloop ascites (Figure 3). Figure 3 – Sequential abdominal ultrasound continued to show a persistent bowel thickening, loss of stratification, several local lymphadenopathies and mild interloop […]

Case Report We present the case of a 54-year-old female, with a previous history of cervical squamous cell carcinoma treated with radical hysterectomy, Piver type III (pT1b N1 R0). On a follow-up pelvic computer tomography (CT) scan, multiple iliac lymphadenopathies (9-13 mm) were detected. The patient was proposed to adjuvant radiotherapy and chemotherapy with cisplatin. One year later, a thoraco-abdominopelvic CT scan was performed, and two periceliac lymph nodes conglomerates with 44 x 29 mm and 27 x 26 mm, suggestive of recurrence of the previous neoplasia, were identified (Fig. 1). Fig. 1 – Endoscopic ultrasound imaging showing a hypoechoic solid mass with central anechoic areas, suggestive of a lymphadenopathy with central necrotic areas.   An endoscopic ultrasound (EUS) was performed using a linear scope, which confirmed the presence of a hypoechoic solid mass with central anechoic areas, with 45 mm of greater diameter, surrounding the celiac trunk and in close contact with the spleno-portal confluence and the splenic artery but, without signs of invasion (Fig. 2). Fig. 2 – Thoraco-abdominopelvic CT scan imaging showing, two periceliac conglomerate of lymph nodes, suggestive of recurrence of the cervival neoplasia.   Other, smaller (10-12mm), periceliac lesions with similar ultrasonographic features, were also found. EUS-guided fine-needle aspiration (FNA) of the major lesion was performed (25G needle – Expect™ Slimline Boston Scientific® – 2 passes) providing samples for rapid on-site evaluation (ROSE). The cytological diagnosis was of granulomatous lymphadenitis (Fig. 3). Material collected for polymerase chain reaction testing, confirmed tuberculous aetiology. Fig. 3 – Cytologic […]

Case Report An 81-years-old female presented to our department with obstructive jaundice (dark urine, pale stools) and a non-specific clinical picture of nausea and appetite loss. Laboratory tests demonstrated a mild leukocytosis with neutrophilia (13.000 cell/mm3; 86%), conjugated hyperbilirrubinemia (7.7 mg/dL), increased aspartate aminotransferase and alanine aminotransferase (10xULN and 8xULN, respectively), slightly increased alkaline phosphatase (2xULN), increased lactate dehydrogenase (10xULN) and serum lipase (3xULN). CA 19.9 was 342 U/mL (Ref value < 37 U/mL). On physical examination, there was no evidence of peripheral lymphadenopathy or hepatosplenomegaly. Abdominal ultrasound (Figure 1-A) revealed a diffuse enlargement of the pancreatic gland. The pancreatic parenchyma was hipoechoic and surrounded by an enhanced peripancreatic fat layer. Also the extra-hepatic and intra-hepatic bile ducts were dilated. The examiner did not notice any dilation of the main pancreatic duct. Contrast-enhanced abdominal computerized tomography (CT, Figure 1-B) revealed a marked homogeneous enlargement of the pancreas. The cephalic portion measured 7cm (antero-posterior diameter), more marked in the uncinate process, without any clear well-defined mass/lesion. There was a dilation of the extra-hepatic and intra-hepatic bile ducts. There was a moderate amount of ascites, especially peri-hepatic, peri-splenic, peri-pancreatic and in the parieto-colic gutter. In addition, there was a significant edema of the subcutaneous tissue of the abdominal wall and, bilaterally pleural effusions were noted. Endoscopic ultrasound (EUS) (Figure 1-C and 1-D) identified an enlarged homogeneous hypoechoic pancreas, without any well-defined lesion, no dilation of the main pancreatic duct, no peripancreatic or celiac enlarged lymph nodes. Using a 19C EchoTip Pro-Core@ HD […]

Case Report A 38 year-old female patient, with no relevant previous medical history, was referred to our unit for evaluation of recurrent left iliac fossa pain, without associated symptoms. No blood test abnormalities were found. Physical examination, pelvic and abdomen ultrasound were normal. Colonoscopy was then performed identifying, at 15 cm from the anal verge, a 3cm bulge in the lumen covered by normal mucosa. These findings were suggestive of a subepithelial lesion (Figure 1). Figure 1. Colonoscopy: 3cm subepithelial lesion, at 15 cm from the anal verge.   Endoscopic ultrasonography (EUS) showed a 30mm hypoechoic heterogeneous mass, with no precise limits and with all layers involved (Figure 2). Figure 2. EUS: 30mm hypoechoic heterogeneous mass, with no precise limits and with all layers involved.   FNA (22G needle) of the lesion was performed and cytologic examination revealed the combination of endometrial glands and stroma. These findings were compatible with endometriosis. Pelvic MRI (Figure 3) and endovaginal ultrasound found no other endometriotic lesions in the pelvis. According to patient preference, hormonal therapy was started and symptoms remission was achieved. Figure 3. Pelvic MRI: coronal (left) and transverse (right) planes. Rectosigmoid endometriosis, with no other endometriotic lesions in the pelvis.   Commentary Subepithelial lesions of the gastrointestinal tract are commonly incidentally discovered during routine upper endoscopy and colonoscopy. In the colon, subepithelial lesions mostly occur in the rectum and cecum, but lipomas (the most frequent colonic subepithelial lesion) may be seen in any part of the colon.1 Lipomas are usually yellowish, […]